Our Research activities

Since its creation,in 1967 under the direction of Dr Raymond Bagnis, the Unit of Medical Oceanography, now renamed Laboratory of Toxic Micro-algaes (LMT), focuses its researches on Ciguatera Fish Poisoning (CFP). It has therefore become a reference in the insular South Pacific region.

From the study of Gambierdiscus dinoflagellate , to the implementation of a ciguatera risk monitoring and prevention system in French Polynesia, LMT is looking forward to develop and strengthen its integrated approach related to this issue.

 

     Epidemiological surveillance     

Ciguatera Fish Poisoning (CFP) is a highly prevalent disease in French Polynesia, where it is a persisting public health problem with real economic consequences.

This program, conducted in partnership with French Polynesia’s Health Directorate aims to clarify the etiology of various types of marine biointoxications present in French Polynesia, as well as to follow the evolution of these intoxications by island and archipelago.

Currently, our efforts are focused on improving the completeness of this reporting program, by giving the opportunity for healthcare professionals and individuals to make an online report directly from this website.

The LMT is also working to extend ciguatera surveillance to other parts of the world in order to estimate and follow the evolution of ciguatera globally.

 

     Study of the genetic diversity and toxic variability within the Gambierdiscus genus.  

One of the first goals of research within the LMT was to develop cultivation techniques suitable for optimum Gambierdiscus micro-algae growth and toxin production.

As a result, an algae bank has been built up over the years, using cell lines isolated from the different islands of French Polynesia where our laboratory has carried out some collection campaigns.

Subsequent studies have shown that Gambierdiscus genus was characterized by both a remarkable genetic diversity and a complex toxinogenesis (unpredictability doubled with an inter- and intra- specific variability of toxins production).

These data emphasize the need: (i) to provide the laboratory with powerful tools (qPCR) enabling detection and real time quantification of toxic strains of the microalgae in natura, for a better appreciation of the ciguatera risk level in a specific fishing area; and (ii) to better understand the toxinogenesis determinism in Gambierdiscus.

 

     Technological watch

Focusing research on ciguatera fish poisoning in French Polynesia has long overshadowed the potential risk related to other poisoning syndromes yet well known by the populations (e.g paralytic, diarrhetic and amnesic syndromes, or other poisonings due to the consumption of turtle or shark flesh).

However marine toxins associated with these syndromes present a great diversity of chemical structures and biological activities, which generates numerous constraints, both scientific and operative, in terms of detection and determination of these compounds.

Another worrying phenomenon: there is, in recent years, an emergence of atypical intoxication syndromes, sometimes linked to unusually high mortality levels, which is likely a result of the concomitant presence of several toxin families within the same marine product.

LMT’s adopted approach to ensure this technological watch is to support the different initiatives promoting the introduction of new monitoring and detection techniques adapted to this complex ecotoxicological context of Polynesian lagoon ecosystems, while ensuring constant improvement of the existing ones.

 

    Ciguatera Fish Poisoning risk management          

In several islands of French Polynesia, the LMT conducts, on a regular basis, field campaigns within local communities with the purpose of a better Ciguatera risk management.

These actions, which are the practical results of advances in basic research, consist, for example, in the establishment of a risk mapping of Polynesian lagoons, which are highly affected by ciguatera: geographic distribution and abundance of the toxinogenic micro-algae, identification of fishing areas and fish species most at risk of ciguatera.

They are also an opportunity to conduct in parallel information, communication and sensitization actions for prevention, to public healthcare professionals, populations and schools.

 

 
                              
 
                              The  Marine Biotoxins team  
  
      Mireille CHINAIN 

Head of Unit 

 
      

Mireille

      P9230431 
Clémence  GATTI                          Research associate               Pathophysiology                           Epidemiological surveillance
 
  
 
 
Taiana DARIUS 
                        Research associate

RBA detection test manager

Qualified expert in radioprotection
Taiana   mel

Mélanie ROUE                            Research associate                    Chemistry of toxins                   SPATT monitoring

   
              
  

Taina REVEL
Senior research technician

Molecular biology (qPCR)- CBA testing

A
Taina   Andr

André UNG                                       Senior research technician        Culture of microalgae                    Field missions

 

 
              
                            

Philippe CRUCHET

Senior research technician

Chemistry of toxins / CTXs mass production

 

Philippe

 

Jrme V

Jérôme VIALLON                        Senior research technician           CBA Toxicology testing                Field missions

 

 
               
   

Kévin HENRY

Research technician

Culture of microalgae / Field missions 

KEVIN        
               
     
         
                             
  Our expertise

Since November 2013, Dr. Mireille Chinain acts as an expert at the French Agency for Food, Environmental and Occupational Health & Safety (ANSES), in the “Ciguatoxins” working group and she is  also acting as an expert at the AIEA since 2014.

Since 2015, Dr. Mireille Chinain and Clémence Gatti intervene as experts at the Intergovernmental Oceanographic Commission of UNESCO (IOC) as part of the "IOC / IPHAB Ciguatera Global Strategy 2015-2019" created to standardize and strengthen research on ciguatera and internationnal risk management.

 

     
         
   
     Collaborations
     Local collaborations

 - UMR 241 - EIO ( Ifremer, IRD, UPF)

- EPHE-CRIOBE

- Bureau de Veille Sanitaire, Direction de la santé (HP. Mallet)

- Direction des ressources Marines et Minières (A. Stein)

- Centre d’Hygiène et de Salubrité Publique

- Centre Hospitalier de Polynésie française (C. Oehler)

 

 

     National collaborations

- Laboratoire Phycotoxines, Ifremer de Nantes (Z. Amzil, P. Hess)

- LED Engineering, Toulouse (C. Furger)

- Université d’Angers, Faculté de médecine (C.Mattei)

- Institut National des Sciences Mathématiques et de leurs  Intéractions, Sorbonne (G. Nuel)

- ARVAM, Reunion island, (JP. Quod, J. Turquet)

- GDR Biochimar

- GDR Phycotox

- ANSES (N. Arnich)

- Station de Biologie Marine of Concarneau ( N. Chomérat)

 

    Regional collaborations

- UR 128 CoRéUs, IRD, Reunion island and New Caledonia (D. Ponton, L. Vigliola)

- CPS, New Caledonia

- Cawthron Institute, New Zealand (T. Harwood, L. Rhodes, K. Smith)

 
    International collaborations

- Center for Coastal Fisheries and Habitat Research, N.O.A.A., USA (P.Tester, W. Litaker)

- Center for Coastal Environmental Health and Biomolecular Research, N.O.A.A., USA (F. Van Dolah)

- International Atomic Energy Agency, I.A.E.A., Monaco ( M.-Y. Bottein-Dechraoui)

- University of North Carolina Wilmington, USA (A. Bourdelais, J. McCall)

- State Key Laboratory for Marine Pollution,Hong Kong (L. Chan, M. Mak)

- Servizio di Tossicologia, Centro Antiveleni di Pavia - Centro Nazionale di Informazione Tossicologica Ospedale, Italia (D. Lonati)

     

 

       
   
      Networks

 Since January 2012, the LMT has been an integral part of the research cluster for Pacific island ecosystems (UMR-241 E.I.O)

    The research cluster for Pacific island ecosystems (UMR- E.I.O.)

 

 

UMR EIO research activities are focused on the analysis of interactions between humans and their environment in the Pacific island ecosystems. UMR EIO brings together academics and researchers from four research institutions: the University of French Polynesia (UPF), the French Research Institute for Exploitation of the Sea (Ifremer), the Research Institute for Development (IRD) and the Louis Malardé Institute (ILM).
The unit is divided into four research teams focused on the following themes:
- Systemic approach of exploited resources (SYREX);
- Integrated -analysis of secondary metabolites (EIMS);
- Health issues in island environments (ESSENTIA);
- Structuring communities: responses to forcing and Biodiversity (FORDIV);


Finally, these themes will be connected to each other by a transverse component "GEOS", based on concepts like geosystems, territories and geodiversity.

 

 

    GDR PHYCOTOX

 

The GdR PHYCOTOX aims to promote exchanges between researchers, to better study not only microalgae’s, ecology, diversity and biology, but also the toxins they produce, the impact on marine organisms and ecosystems, as well as the potential consequences to the public health and socioeconomic levels. Gdr PHYCOTOX objective is to unite these different clusters in a structured network of diverse skills and complementary approaches. One of the group’s main goals will be to facilitate the multidisciplinary of approaches, thus promoting the quality and originality of research on toxic microalgae and phycotoxins in France and French OCTs.

 

    PACE-NEt+

 

Through the PACE-NET + project, the European Union, which maintains a close longstanding relationship with the Pacific region, aims for enhancing its profile and reinforcing cooperation in Science Technology and Innovation (STI) with the South Pacific island nations. Strengthening bi-regional dialogue is a key step in achieving increased EU-Pacific collaboration towards these societal challenges. In the view of mutual benefit for Europe and the Pacific region, PACE-Net Plus aims to:

- Support EU-Pacific policy dialogue in Science, Technology and Innovation issues;

- Reinforce EU-Pacific ST&I cooperation, focusing on 3 major societal challenges;

- Encourage the coordination of European actions and policies targeting the Pacific by promoting the implementation of joint actions;

- Enhance cooperation on innovation issues, by helping to bridge the gap between public and private sectors;

- Strengthen Pacific-EU research cooperation partnerships, by promoting Horizon 2020 and other

programmes within the Pacific research community, and communicating Pacific opportunities to European.

 

 

    GOPS

 

The GOPS is a research observatory or "consortium of existing or future observatories», that will strengthen the pooling of resources among its members, by including all existing systems. The GOPS aims to address scientific questions of global and regional scale, based on observation and long-term monitoring of the environment and ecosystems, but which may have an impact at the local level.

     
 

 

     
   
  Recent Publications
    Publications ( 2009-2016)

 

Roué M, Dr, Darius HT, Picot S, Ung A, Viallon J, Gaertner-Mazouni N, Sibat M, Amzil Z, Chinain M. 2016. First evidence of the bioaccumulation of ciguatoxins in giant clams (Tridacna maxima) exposed to Gambierdiscus spp. cells. Harmful Algae (accepted)

HARDISON DR, HOLLAND WC, McCALL JR, BOURDELAIS AJ, BADEN DG, DARIUS HT, CHINAIN M, TESTER PA, SHEA D, FLORES QUINTANA HA, MORRIS Jr. JA, LITAKER RW. (2015). Fluorescent Receptor Binding Assay for detecting ciguatoxins in fish. PlosOne DOI:10.1371/journal.pone.0153348, pp.1-19.

ROUE M, DARIUS HT, PICOT S, UNG A, VIALLON J, GAERTNER-MAZOUNI N, SIBAT M, AMZIL Z, CHINAIN M. (2015). First evidence of the bioaccumulation of ciguatoxins in giant clams (Tridacna maxima) exposed to Gambierdiscus spp. cells. Harmful Algae, (accepté)

Gatti C, Darius HT, Chinain M, Lonati D. 2015. First report of a mass-poisoning outbreak following the consumption of Tectus niloticus (Gastropod) in French Polynesia : a novel pathway of Ciguatera Fish Poisoning ? IOC newsletter on Toxic Algae and Algal Blooms, n°50, January 2015, http://www.e-pages.dk/ku/1086/

Ledreux A, Brand H, Chinain M, Dechraoui Bottein M-Y, Ramsdell J.S. 2014. Dynamics of ciguatoxins from Gambierdiscus polynesiensis in the benthic herbivore Mugil cephalus: Trophic transfer implications.Harmful Algae 39:165-174.

Pawlowiez R, Morey JS, Darius HT, Chinain M, Van Dolah FM. 2014. Transcriptomesequencing reveals single domain type    I-like Polyketide Synthases in the toxic dinoflagellate Gambierdiscus polynesiensis. Harmful Algae, 36:29-37.

Roué M, Gugger M, Golubic S, Amzil Z, Araoz R, Turquet J, Chinain M, Laurent D. 2014.Marine cyanotoxins potentially harmful to human health. In: Labarre S & Kornprobst JM (Eds.) Outstanding marine molecules - from natural history to human welfare, Wiley France (sous presse).

Gaboriau M, Ponton D, Darius HT, Chinain M. 2014. Ciguatera fish toxicity in French Polynesia : size does not always matter. Toxicon 84:41-50, http://dx.doi.org/10.1016/j.toxicon.2014.03.006).

Braidy N, Matin A, Rossi F, Chinain M., Laurent D, Guillemin G. 2014. Neuroprotective effects of rosmarinic acid on ciguatoxin in primary human neurons. Neurotoxicity Research, 25(2):226-34.

Chinain M, Gatti C, Roué M, Laurent D, Darius.HT.2014. Ciguatéra : aspects écologiques, biologiques et toxicologiques. Revue Francophone des Laboratoires. 460(2): 27-39.

Pawlowiez R, Darius HT, Cruchet P, Rossi F, Caillaud A, Laurent D, Chinain M. 2013. Evaluation of seafood toxicity in the Australes archipelago (French Polynesia) using the neuroblastoma cell-based assay. Food additives and contaminants: Part A 30(3): 567-586.

Darius HT, Drescher O, Ponton D, Pawlowiez R, Laurent D, Dewailly E, Chinain M. 2013. Use of folk tests to detect ciguateric fish: a scientific evaluation of their effectiveness in Raivavae Island (Australes, French Polynesia). Food additives and contaminants: Part A 30(3): 550-566.

Chinain M, Gatti C, Darius HT. 2013. Ciguatéra: aspects physiopathologiques et cliniques. Bulletin de Veille Sanitaire Cire Antilles-Guyane, N°3/Avril 2013, 1-6.

Hossen, V, Velge P, Turquet J, Chinain M, Laurent D, Krys S. 2013. La ciguatéra en France : une intoxication alimentaire dans les départements et régions d'outre-mer aux portes de la métropole ? Bulletin Epidémiologique ANSES, 56 : 3-8.

Reguera B, Boisson F, Darius HT, Dechraoui-Bottein MY. 2013. Toxic micro-algal blooms: what can nuclear techniques provide for their management? In: Isotopes in Hydrology, Marine Ecosystems and Climate Change Studies, Proceedings of an International Symposium, IAEA, Monaco, 27 mars –1 avril 2011, Vol.1, 483-492.

Laurent D, Kerbrat AS, Darius HT, Rossi F, Yeeting B, Haddad M, Golubic S, Pauillac S, Chinain M. 2012. Ciguatera Shellfish Poisoning (CSP), a new ecotoxicological phenomenon. From cyanobacteria to humans via giant clams. In: Food Chain: New Research, Jensen MA & Muller DW, editors. Nova Publishers. New-York Chapter I: 1-44.

Rossi F, Jullian V, Pawlowiez R, Kumar-Roiné S, Haddad M, Darius HT, Gaertner-Mazouni N, Chinain M., Laurent D. 2012. Protective effect of Heliotropium foertherianum (Boraginaceae) folk remedy and its active compound, rosmarinic acid, against a Pacific ciguatoxin. J Ethnopharmacol 143(1): 33-40.

Vandersea MW, Kibler SR, Holland WC, Tester PA, Schultz TF, Faust MA, Holmes MJ, Chinain M, Litaker RW. 2012. Development of semi quantitative PCR assays for the detection and enumeration of Gambierdiscus species (Gonyaulacales, Dinophyceae). J. Phycol. 48(4): 902-915.

Villeneuve A, Laurent D, Chinain M, Gugger M, Humbert JF. 2012. Molecular characterization of the diversity and potential toxicity of cyanobacterial mats in two tropical lagoons in the South Pacific Ocean. J. Phycol., 48: 275-284.

Kerbrat AS, Amzil Z, Pawlowiez R, Golubic S, Sibat M, Darius HT, Chinain M, Laurent D.2011. First evidence of palytoxin and 42-hydroxy-palytoxin in the marine cyanobacterium Trichodesmium. Marine Drugs, 9(4): 543-560.

Kumar-Roiné S, Darius HT, Matsui M, Fabre N, Haddad M, Chinain M, Pauillac S, Laurent D. 2011. A review of traditional remedies of Ciguatera Fish Poisoning in the Pacific. Phytotherapy Research, 25: 947-958.

Kerbrat AS, Darius HT, Pauillac S, Chinain M, Laurent D. 2010. Detection of ciguatoxin-like and paralysing toxins in Trichodesmium spp. from New Caledonia lagoon. Marine Pollution Bulletin, 61(7-12): 360-366.

Molgó J, Laurent D, Pauillac S, Chinain M, Yeeting B. 2010. Special issue on “Ciguatera and Related Biotoxins”. Toxicon, 56(5): 653-655.

Chinain M, Darius HT., Ung A, Tchou Fouc M, Revel T, Cruchet P, Pauillac S, Laurent D. 2010. Ciguatera risk management in French Polynesia: The case study of Raivavae Island (Australes Archipelago). Toxicon, 56(5): 674-690.

Chinain M, Darius HT, Ung A, Cruchet P, Wang Z, Ponton D, Laurent D, Pauillac S. 2010. Growth and toxin production in the ciguatera-causing dinoflagellate Gambierdiscus polynesiensis (Dinophyceae) in culture. Toxicon, 56(5): 739-750.

Litaker RW, Vandersea MW, Faust MA, Kibler SR, Nau A, Chinain M, Holmes MJ, Holland WC, Tester PA. 2010. Global distribution of ciguatera causing dinoflagellates in the genus Gambierdiscus. Toxicon, 56(5): 711-730.

Méjean A, Peyraud-Thomas C, Kerbrat AS, Golubic S, Pauillac S, Chinain M, Laurent D. 2010. First identification of the neurotoxins anatoxin-a and homoanatoxin-a from Hydrocoleum spp. marine cyanobacterium. Toxicon, 56(5): 829-835.

Golubic S, Abed RMM, Palińska K, Pauillac S, Chinain M, Laurent D. 2010. Marine toxic cyanobacteria: diversity, environmental responses and hazards. Toxicon, 56(5): 836-841.

Matsui M, Kumar-Roiné S, Darius HT, Chinain M, Laurent D, Pauillac S. 2010. Pacific ciguatoxin 1B-induced modulation of inflammatory mediators in a murine macrophage cell line. Toxicon, 56(4):776-784.

Caillaud A, de la Iglesia P, Darius HT, Pauillac S, Aligizaki K, Fraga S, Chinain M, Diogène J. 2010. Update on the methodologies available for ciguatoxin determination. A perspective to confront the onset of Ciguatera Fish Poisoning in Europe. Marine Drugs, 8(6): 1838-1907.

Litaker RW, Vandersea MW, Faust MA, Kibler SR, Chinain M, Holmes MJ, Holland WC, Tester PA. 2009. Taxonomy of Gambierdiscus including four new species, Gambierdiscus caribaeus, Gambierdiscus carolinianus, Gambierdiscus carpenteri and Gambierdiscus ruetzleri (Gonyaulacales, Dinophyceae). Phycologia48(5): 344-390.

Kumar-Roiné S, Matsui M, Reybier K, Darius HT, Chinain M, Pauillac S, Laurent D. 2009. Ability of certain plant extracts traditionally used to treat ciguatera fish poisoning to inhibit nitric oxide production in RAW264.7 macrophages. J Ethnopharmacol, 123(3):369-377.

Matsui M, Kumar-Roiné S, Darius HT, Chinain M, Laurent D, Pauillac S. 2009. Characterisation of the anti-inflammatory potential of Vitex trifolia L. (Labiatae), a multipurpose plant of the Pacific traditional medicine. Journal of Ethnopharmacology, 126(3): 427-433.

Chateau-Degat ML, Chinain M, Darius HT, Dewailly E, Mallet HP. 2009. Surveillance épidémiologique de la ciguatéra en Polynésie française. Bulletin Epidémiologique Hebdomadaire, 48-50: 522-525.

 

 

    Oral communications

GATTI C, DARIUS HT, ROUE M, LONATI D, SIBAT-DUBOIS M, SAVAR V, AMZIL Z & CHINAIN M. (2015). Novel case report of a Ciguatera Shellfish Poisoning cluster following the consumption of Tectus niloticus (Gastropod) in French Polynesia.AG du GDR PHYCOTOX, 31 mars – 02 avril 2015, Brest, France.

GATTI C. (2015). La ciguatéra, nouveau syndrome et activités du Laboratoire de recherches sur les micro-algues toxiques en Polynésie française. Séminaire « Intoxications aux ciguatoxines : problématiques liées au diagnostique et opportunités de recherche », 8 avril 2015, Centre Antipoison et de Toxicovigilance (CAV-CNIT), Pavie, Italie.

CHINAIN M. (2015).  La ciguatéra : une fatalité pour les populations polynésiennes ? TEDx PPT Women, 28 mai 2015, Maison de la Culture, Papeete Tahiti (sur invitation).https://www.youtube.com/playlist?list=PLkKv42gxLF_sGIhhRDCnX6SxpO9PunJEd

GATTI C, DARIUS HT, CHINAIN M. (2015). Indicateurs d’impact du réchauffement des eaux sur les efflorescences ciguatériques et l’apparition de nouvelles zones endémiques. Symposium « Vulnérabilité des îles basses polynésiennes et du Pacifique face aux effets du changement climatique ». 30 juin-02 juillet 2015, Papeete, Tahiti, Polynésie français

CHINAIN M. (2015). Enjeux sanitaires dans les Environnements Insulaires Océaniens- bilan de l’équipe ESSENTIA de l’UMR 241 EIO, 20 août 2015, Université de Polynésie française, Tahiti.

DELESALLE B, HENRY K, RODIER M, UNG A, LO-YAT A, MORELLE J, GATTI C, BROTHERSON K, SOYEZ C, VIALLON J, LE MOULLAC G, CHINAIN M.  (2015). Efflorex : étude du potentiel toxique et nutritionnel des efflorescences algales dans les atolls perlicoles de Polynésie française. Colloque LABEX, 7-9 septembre 2015, Paris.

LO-YAT A, LE MOULLAC G, SOYEZ C, BROTHERSON K, RODIER M, MORELLE J, HENRY K, UNG A, VIALLON J, GATTI C, DELESALLE B, CHINAIN M. (2015). Evaluation du potentiel nutritionnel de microalgues efflorescentes de lagons d'atoll dans les élévages d'huître perlière Pinctadamargaritifera. Colloque LABEX, 7-9 septembre 2015, Paris.

CHINAIN M (2015). Présentation programme Efflorex. Atelier Takaroa - Séminaire de restitution POLYPERL. 03 novembre 2015, Tahiti, Polynésie française.

GATTI C, Mallet HP, Darius T, M. Chinain M. 2015. Surveillance de la Ciguatéra : Mise en place d’un outil numérique et participatif en Polynésie française. 4èmes journées interrégionales de Veille Sanitaire des Antilles Guyane, Fort de France, Martinique, 05-07 novembre 2015

DECHRAOUI BOTTEIN MY, TABADDA RS, CHINAIN M, DARIUS HT, AMAYA O, PORNTEPKASEMSAN B,ROMARIN M, TESTER PA, ENEVOLDSEN H, VAN DOLAH FM. (2015). Linking nuclear science and seafood safety: Reliability of the receptor binding assay for PSP and ciguatera toxins. 8th US HAB Symposia, Long Beach, CA, USA, 15-19 novembre 2015.

Chinain M., Pawlowiez R., Caillaud A., Ung A., Cruchet P., Harwood T., Gatti C. M., Darius H. T. 2014 « Integrated study of a fish poisoning outbreak in Rapa (Australes, French Polynesia) ». 16th International Conference on Harmful Algae. ISSHA, 27-31 October, Wellington, New-Zealand.

Roué M., Picot S., Ung A., Viallon J., Sibat M. ,Amzil Z., Gaertner-Mazouni N., Chinain M., Darius H. T. 2014 « Giant clams: could they represent a new vector of Ciguatera? » 16th International Conference on Harmful Algae. ISSHA, 27-31 October, Wellington, New-Zealand.

Gatti C. M., Darius H. T., Ponzo N., Sevrain Hiribarren B., Chinain M. 2014 « Ciguatera 2.0:A website as a helpful tool to improve ciguatera surveillance, risk management and research advances » 16th International Conference on Harmful Algae. ISSHA, 27-31 October, Wellington, New-Zealand.

Chinain M, Darius HT, Gatti C, Roué M, Rossi F, Laurent D. 2013. « Integrated approach to the study of Ciguatera Fish Poisoning: the example of French Polynesia”. GEOHAB Open Science Meeting, 24-26 avril 2013, UNESCO, Paris, France.(sur invitation)

Chinain M. 2013. “Ciguatera Research in French Polynesia”. State Key Laboratory in Marine Pollution Annual Meeting, 12-14 Janvier 2013, Shenzhen, Chine. (sur invitation)

Rossi F, Jullian V, Pawlowiez R, Haddad M, Darius HT, Chinain M, Richert L, Gaertner-Mazouni N, Laurent D. 2012. Protective effect of Heliotropium foertherianum and rosmarinic acid against Pacific ciguatoxins. 13ième Congrès International de la Société d’Ethnopharmacologie, 2-6 septembre 2012, Graz, Autriche.

Roué M, Cruchet P, Ung A, Darius HT, Chinain M, Laurent D. 2012. Giant clams : New Vectors of Ciguatera ? 20th Meeting of the French Society of Toxinology SFET, 10-11 Décembre 2012, Paris, France.

Gaertner-Mazouni N, Remoissenet G, Andrefouet S, Stein A, Laurent D, Chinain M, Charpy L, Lo Wing M, Jouve JM. 2012. Giant clam fisheries in French Polynesia : constraints and new issues ? 12th International Coral Reef Symposium, 9-13 July 2012, Cairns, Queensland, Australia.

Gugger M, Villeneuve A, Echenique I, Laurent D, Chinain M, Turquet J, Humbert JF, Golubic S. 2012. Cyanobacterial mats in tropical lagoons of Indian and Pacific Oceans. International Symposium on Coral Reefs, 12th International Coral Reef Symposium, 9-13 July 2012, Cairns, Queensland, Australia.

Darius HT, Pawlowiez R, Caillaud A, Tchou Fouc M, Ung, A, Cruchet P, Revel T, Laurent D, Chinain M.2011. Evaluation of ciguatera risk in Raivavae islands (Australes archipelago) and Fakarava atoll (Tuamotu archipelago) in French Polynesia from 2007-2011. CRP AIEA, Monaco, 28 nov.-2 déc. 2011.

Reguera B, Boisson F, Darius HT, Bottein MY. 2011. Toxic microalgal blooms: what can nuclear techniques provide for their management? International Symposium on Isotopes in Hydrology, Marine Ecosystems, and Climate change Studies. 27 mars- 1er avril 2011, Musée Océanographique, Monaco.

Villeneuve A, Echenique-Subiabre I, Laurent D, Chinain M, Turquet J, Humbert J-F, Golubic S, Gugger M. 2011. Benthic Cyanobacterial mats in tropical lagoons. 8th European Workshop on Molecular Biology of Cyanobacteria, Finland, 28 Août-1 septembre 2011.

Quod JP, Turquet J, Darius HT, Laurent D, Chinain M. 2011. State of the art on benthic toxic dinoflagellates in French oversea territories with special focus on Ostreopsis. International Conference on Ostreopsis development, 4-8 avril 2011, Villefranche-sur-mer, France.

Darius HT. 2010. IAEA Regional Project to implement RBA for STXs and CTXs in the Asian and Pacific region. 30 août-3 septembre 2010,Nelson, New-Zealand.

Litaker RW, Vandersea MW, Kibler SR, Faust MA, Chinain M, Holland WC, Holmes MJ, Tester PA. 2010. Gambierdiscus taxonomy and global distribution. 10-13 juillet 2010. Phycological Society of America annual meeting, Michigan State University, USA.

Litaker RW, Vandersea MW, Kibler SR, Chinain M, Holland WC, Holmes MJ, Faust MA, Tester PA. 2010. Gambierdiscus taxonomy – Morphology and DNA methods. GEOHAB Open Science Meeting on Harmful Algal Blooms in Benthic Systems, 21-23 Juin 2010, Honolulu, Hawaii, USA.

Chinain M, Darius HT, Ung A, Tchou Fouc M, Revel T, Cruchet P, Pauillac S, Laurent D. 2009. Ciguatera risk assessment campaigns in French Polynesia: what are their benefits?". 11th Pacific Science Inter-Congress, 2-6 Mars 2009, Tahiti, Polynésie française.

Kerbrat AS, Darius HT, Golubic S, Pauillac S, Chinain M, Laurent D. 2009. Ciguatera Shellfish Poisoning: a new ecotoxicological phenomenon related to marine Oscillatoriales (cyanobacteria) blooms? 11th Pacific Science Inter-Congress, 2-6 Mars 2009, Tahiti, Polynésie française.

 

 

    Poster communications

 LONATI D, GATTI C, ZANCAN A, DARIUS HT, FLEURE M,  CHINAIN M, BUONOCORE M, LOCATELLI CA. (2015). Novel Ciguatera shellfish poisoning (CSP) cluster after consumption of Tectus niloticus, a gastropod, in Nuku-Hiva, French Polynesia. 35th International Congress of the European Association of Poisons Centres and Clinical Toxicologists (EAPCCT), 26-29 Mai 2015, Malte, Italie, Clinical Toxicology 53: 278.

Darius H. T., Roué M., Ung A., Cruchet P., Revel T., Viallon, J., Suhas E., Gatti C. M., Chinain M. 2014 « Ecotoxicological characterization of 3 different lagoons of FrenchPolynesia : Tikehau, Kaukura and Mangareva. » 16th International Conference on Harmful Algae. ISSHA, 27-31 October, Wellington, New-Zealand.

Roué M., Ung A., Darius H. T., Harwood T., Chinain M. 2014 « Evaluation of Solid-Phase AdsorptionToxin Tracking devicesfor the monitoring of Ciguatera ». 16th International Conference on Harmful Algae. ISSHA, 27-31 October, Wellington, New-Zealand.

Gatti C, Darius HT, Chinain M. 2013. Consommation de poissons lagonaires et ciguatéra. Conférence régionale francophone sur l’alimentation, 3-5 octobre 2013, Tahiti.

Gatti C, Darius HT, Chinain M. 2013. Consommation de poissons : entre risques et bénéfices pour la santé. Conférence régionale francophone sur l’alimentation, 3-5 octobre 2013, Tahiti.

Rossi F, Laurent D, Richert L, Gaertner-Mazouni N, Chinain M. 2013. A traditional plant remedy, Heliotropium foertherianum, against Ciguatera Fish Poisoning. XIIth Pacific Science Inter-congress, 8-12 juillet 2013, USP Suva, Fidji

Pawlowiez R, Darius HT, Ung A, Morey J, Laurent D, Van Dolah FM, Chinain M. 2012. A la recherche de marqueurs moléculaires de toxicité chez Gambierdiscus. Doctoriales UPF, 25-27 Avril 2012, Université de Polynésie française.

Meunier E, Coste A, Laurent D, Chinain M, Pipy B. 2012. Impact of ciguatoxins on innate immune cells. International Coral Reef Symposium, 9-13 juillet 2012, Cairns, Australie.

Rossi F, Richert L, Gaertner-Mazouni N, Darius HT, Chinain M, Laurent D. 2011. Valorisation industrielle d'un remède traditionnel pour le traitement des intoxications ciguatériques. Doctoriales UPF, 27-29 avril 2011, Assemblée de Polynésie, Tahiti.

Echenique I, Villeneuve A, Laurent D, Chinain M, Humbert JF, Turquet J, Gugger M. 2011. Benthic cyanobacterial mats in tropical lagoons. Journées du Département de Microbiologie de l’Institut Pasteur, 14-18 mars 2011, Institut Pasteur, Paris France.

Darius HT, Ung A, Tchou Fouc M, Revel T, Cruchet P, Villiers L, Pauillac S, Laurent D, Chinain M . 2009. Application of the Receptor-Binding assay for the evaluation of Ciguatera risk in French Polynesia. 11th Pacific Science Inter-Congress, 2-6 Mars 2009, Tahiti, Polynésie française.Château-Degat L, Chinain M, Darius HT, Legrand AM, Huin-Blondey MO, Nguyen NL, Chansin R, Dewailly E. 2009. Ciguatera, from bloom to itch; Last lessons from French Polynesia. 11th Pacific Science Inter-Congress, 2-6 Mars 2009, Tahiti, Polynésie française.

Matsui M, Kumar-Roiné S, Chinain M, Laurent D, Pauillac S. 2009. Modulation of iNOS and cytokines expression by plants extracts traditionally used for the treatment of ciguatera in the South Pacific: characterization of their anti-inflammatory activity. 11th Pacific Science Inter-Congress, 2-6 Mars 2009, Tahiti, Polynésie française.

Kumar-Roiné S, Matsui M, Reybier K, Darius HT, Chinain M, Laurent D, Pauillac S. 2009. Nitric oxide production in Pacific ciguatoxin-1B-stimulated RAW 264.7 cells: evidence for the role of NO pathway in the pathophysiology of Ciguatera Fish Poisoning in a mouse model. 11th Pacific Science Inter-Congress, 2-6 Mars 2009, Tahiti, Polynésie française

Kerbrat AS, Videault A, Pauillac S, Chinain M, Laurent D. 2009. Ciguatera and man’s influence in New Caledonia: the Bay of Prony, construction site of nickel plant and Ouvea tropical atoll “safe” from ciguatera outbreaks. 11th Pacific Science Inter-Congress, 2-6 Mars 2009, Tahiti, Polynésie française.

 

 

     
           
   

 

                                      

     

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